Jimin Wang

This paper uses a machine learning model to generate new anti-PD-1 antibodies with improved potency, validated through molecular dynamics simulations and experimental testing.

This study identifies a novel protein fold in KSHV ORF24 that enables direct binding to RNAPII CTD, facilitating viral late gene transcription through structural mimicry of a host transcription factor.

The paper presents cryo-EM structures of Photosystem I with alternative quinones, revealing asymmetry in quinone binding and exchange.

The paper uses in situ cryo-EM to visualize human ribosome structures and functional states, revealing new protein interactions and polysome interfaces.

This study reveals how tetracyclines target the bacterial ribosome using cryo-EM structures, showing species-specific interactions and a new mechanism for antibiotic action.

This study investigates how Ebselen modulates MIF-2 structure, catalysis, and signaling through cysteine residues, revealing its impact on trimer stability and function.

This paper investigates the triple-action inhibitory mechanism of deucravacitinib on TYK2, revealing its inhibition in three distinct states and structural basis for selectivity.