Author

Xavier Trepat

IBEC;Primary ORCID profile (0000-0002-7621-5214 · 15 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Xavier TrepatiD15 papers · Institució Catalana de Recerca i Estudis Avançats

Biology Disciplines

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Biophysics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Alejandro Bernardo· 1 shared Amelia Parker· 1 shared Ananyo Maitra· 1 shared Andrea Malandrino· 1 shared Andrew G Clark· 1 shared Anna Labernadie· 1 shared Annalisa Calo· 1 shared Anthony Simon· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiophysics

Alejandro Bernardo

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3 papers

Recent·Most cited

Nanomechanical phenotyping uncovers a non-canonical smooth muscle-like hypercontractility program in lung squamous cell carcinoma myofibroblasts

Annalisa Calo, Alejandro Bernardo, Natalia Diaz Valdivia, Anna Labernadie, Victoria Batto, Jose Rodriguez-Rojas, Miguel Vizoso, Beatriz Cantero, Marselina Arshakyan, Marc Rico Pasto, Larissa Huetter, Amelia Parker, Mohit Kumar, Nuria Gavara, Gabriel Gomila, , Jordi Alcaraz

The paper identifies a non-canonical smooth muscle-like hypercontractility program in LUSC myCAFs using nanomechanical phenotyping, linking it to tumor mechanics and adverse outcomes.

bioRxiv · Nov 9, 2026 · PreprintBiophysics

Viscoelastic relaxation of collagen networks provides a self-generated directional cue during collective migration

Andrew G Clark, Ananyo Maitra, Cécile Jacques, Anthony Simon, Carlos Pérez-González, Xavier Trepat, Raphaël Voituriez, Danijela Matic Vignjevic

The paper shows that cell clusters migrate persistently on collagen networks by generating asymmetric gradients through viscoelastic relaxation, independent of internal polarity.

Nature Materials · Oct 1, 2022Peer-reviewedBiophysics

Non-Elastic Remodeling of the 3D Extracellular Matrix by Cell-Generated Forces

Andrea Malandrino, Michael Mak, Xavier Trepat, Roger D. Kamm

The paper shows cell-generated forces irreversibly alter ECM density and architecture in minutes, linking plasticity to force-driven crosslink unbinding.

bioRxiv · Sep 27, 2017 · PreprintBioengineering