Xavier Trepat

This paper develops a minimal physical model to explain haptotaxis and oscillatory cell migration by linking adhesion strength to protrusive actin activity.

The paper shows that keratin bundling in epithelial cells under stretch allows the nucleus to escape its keratin cage, providing a mechanism for tissue adaptation to mechanical stress.

This study investigates how fibronectin matrix remodeling by cancer-associated fibroblasts (CAFs) influences their nematic dynamics, revealing aging and freezing of defect motion in the ECM.

The paper shows that fibrillar adhesions control nuclear mechanical response timescales through vimentin cytoskeleton anchoring via plectin 1f.

This paper introduces a strategy to program tissue shape transformations through nematic organization of cellular forces, demonstrating reproducible 3D shape generation upon tissue detachment.

The paper develops a unified framework connecting sub-cellular actomyosin dynamics to tissue mechanics, explaining various epithelial behaviors under stretch.

This study shows YAP in cardiac fibroblasts controls ECM structure and fibroblast alignment, affecting cardiomyocyte function and tissue integrity.

This study shows cells exhibit complex migration patterns along haptotactic gradients, including oscillations and directed movement, and develops a biophysical model to explain these behaviors.

This paper introduces DNA-based hydrogel microparticles with tunable mechanical properties for 3D cellular systems, showing they can be remodeled by fibroblast spheroids based on their stiffness.

The paper investigates the mechanical mechanisms of intestinal cell extrusion, showing that it is driven by calcium-triggered myosin 2A mesh dissolution and lamellipodial forces, with extrusion direction determined by these structures.

This study investigates the mechanics of epithelial buckling by combining experiments and simulations, revealing multiscale wrinkling dynamics and how they can be controlled through curvature and contractility.

This paper introduces 3D-TFM to measure cell-substrate forces in 3D environments and shows cells switch from contractile to extensile behavior as volume decreases.

The paper uses optogenetic Rac1 activation to generate leader cells and shows that collective cell migration requires global mechanical organization rather than autonomous leader action.

The paper shows that nucleocytoplasmic transport (NCT) in cell monolayers responds to mechanical forces but not cell density, contrasting with YAP's response to both mechanics and cell density.

This study shows that cell-matrix forces increase during the loss of naive pluripotency in mESCs and are required for this process.

This study identifies mechanical phenotype differences between LGR5+ and LGR5- colorectal cancer cells, linking them to membrane to cortex attachment proteins and metastatic potential.

This paper extends a biochemical model of circadian rhythms to include mechanical effects, showing that mechanical signals must be within an optimal range for oscillations to occur.

This paper introduces OptoShroom3, an optogenetic tool to control apical constriction in mammalian tissues, demonstrating its ability to induce 3D morphological changes in neural organoids.

This study investigates how mechanical and chemical cues influence the migration of Cajal-Retzius cells in the developing neocortex, showing that mechanical properties and route stiffness affect their distribution.

The paper shows that competition between biochemical and mechanical cues regulates endothelial cell polarity, driving vascular morphogenesis through tension shifts.