A durably colonizing engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitis
Qixiang Zhao, Yong Ding, Sen Yan, Haohan Ma, Yicun Wang, Siqi Guo, Xi Luo, Yanli Pang, Changtao Jiang, Kai Wang
This paper develops a safety-optimised native E. coli strain for long-term gut colonisation and sustained therapeutic delivery, showing efficacy in treating colitis and metabolic dysfunction.
bioRxiv · Aug 4, 2026 · PreprintMicrobiology