An antifungal with a novel mechanism of action discovered via resistance gene-guided genome mining
Bruno Perlatti, Sandeep Vellanki, Yalong Zhang, Yi‐Ming Chiang, Yingxia Hu, Mengdi Yuan, Kyle L. Dunbar, Abigail Fine, Michelle F. Grau, Sheena Claire Li, Timothy O’Donnell, Rajani Marthappa Shenoy, Hongtao Li, Hui Shi, Xia Xu, , Colin J. B. Harvey
This study identifies a novel antifungal compound targeting ALS, validated through genome mining, biochemical assays, and a mouse model of invasive aspergillosis.
ACS Central Science · Jan 31, 2026Peer-reviewedBioengineering