Ning Li

Endothelial protein C receptor is an entry receptor for Langya and related parahenipaviruses

The paper identifies endothelial protein C receptor (EPCR) as an entry receptor for Langya and related parahenipaviruses and describes the structural basis of this interaction.

Genome-wide association study and genetic differentiation analysis reveal the genetic basis of Vibrio harveyi resistance in blackspotted croaker (Protonibea diacanthus)

This study identifies genetic basis of Vibrio harveyi resistance in blackspotted croaker using GWAS and F_ST analysis, revealing key genes and pathways involved in RNA metabolism.

MEDUSA: Maintaining Entire DNA Duplexes for Utmost Sequencing Accuracy

MEDUSA improves sequencing accuracy by minimizing DNA duplex resynthesis during library preparation, achieving lower residual SNV frequency in genomic and cell-free DNA.

Benchmarking of duplex sequencing approaches to reveal somatic mutation landscapes

This study benchmarks six duplex sequencing technologies to evaluate their performance in detecting somatic mutations across different genomic contexts and tissue types.

An epigenetic basis for sustained inflammatory epithelial progenitor cell states in Crohn's disease

The paper identifies an inflammatory secretory progenitor cell state in Crohn's disease patients and shows its epigenetic regulation in stem cells.

Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques

This study shows that macaques can elicit human-like broadly neutralizing antibodies against influenza HA stem regions, with similar immunogenetic and structural features.

Identification of novel human cellular substrates of Staphylococcus aureus serine protease SplB

This study identifies novel human substrates of Staphylococcus aureus protease SplB, revealing its cleavage of intermediate filaments and IgG, suggesting roles in immune evasion and tissue invasion.

Exploring Erdr1-Mid1 Axis: Shared Risk Factors and Molecular Mechanisms in Aging and Degenerative Diseases

This study identifies Erdr1 and Mid1 as shared risk factors for aging and degenerative diseases, showing they modulate oxidative stress through alternative splicing and activation, and proposes therapeutic strategies to mitigate cellular damage.

HKU5 bat merbecoviruses use divergent mechanisms to engage bat and mink ACE2 as entry receptors

This study identifies bat and mink ACE2 as receptors for HKU5 merbecovirus, revealing distinct receptor interactions and highlighting mustelids as potential intermediate hosts.

Transcriptome analysis of resistant and susceptible pepper (Capsicum annuum L.) in response to Xanthomonas campestris pv. Vesicatoria

This study compares transcriptome responses of resistant and susceptible pepper cultivars to Xanthomonas campestris pv. Vesicatoria infection, identifying differentially expressed genes and pathways involved in resistance.

Scalable and Accurate Drug-target Prediction Based on Heterogeneous Bio-linked Network Mining

The paper introduces a drug-target prediction method that improves accuracy and scalability by integrating heterogeneous networks, Node2Vec for feature learning, and a hybrid model with negative sampling, achieving high AUC ROC scores.

Dectin-3 recognizes cryptococcal glucuronoxylomannan to initiate host defense against cryptococcosis

This study identifies Dectin-3 as a receptor for cryptococcal GXM, showing it activates immune pathways and protects against infection.

Gene mapping of nine agronomic traits and genome assembly by resequencing a foxtail millet RIL population

This study resequences a foxtail millet RIL population to improve genome assemblies and map genes for nine agronomic traits.

Accelerated DNA evolution in rats is driven by differential methylation in sperm

The paper investigates epigenetic and DNA variation in rat subspecies, finding that differential methylation in sperm drives accelerated DNA evolution through environment-associated chromatin changes.

Online Self-Report Data for Duchenne Muscular Dystrophy confirms natural history and can be used to assess for therapeutic benefits

This study uses online self-report data from DuchenneConnect to show that corticosteroid use delays loss of ambulation in DMD, with deflazacort more effective than prednisone.