HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes
Hongchen Li, Xinchao Zhang, Xiaoben Liang, Shuyan Li, Ziyi Cui, Xinyu Zhao, Kai Wang, Bingbing Zha, Haijie Ma, Ming Xu, Lei Lv, Yanping Xu
This study identifies an HNF4-TET2-FBP1 axis that regulates gluconeogenesis and shows metformin's effect on this pathway in type 2 diabetes.
bioRxiv · Sep 29, 2024Cell Biology