A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation
Wuhong Pei, Lisha Xu, Zelin Chen, Claire C. Slevin, Kade P. Pettie, Stephen Wincovitch, NISC Comparative Sequencing Program, Beatrice B. Barnabas, Sean Black, Gerard G. Bouffard, Shelise Y. Brooks, Holly Coleman, Lyudmila Dekhtyar, Xiaobin Guan, Joel Han, , Shawn Michael Burgess
The paper identifies gemin3 as a regeneration-essential gene in zebrafish and shows smn1, gemin3, and gemin5 inhibit the ErbB pathway to promote cell proliferation during tissue regeneration.
npj Regenerative Medicine · Mar 25, 2020Peer-reviewedGenetics