ABCG5 ABCG8-independent mechanisms fail to maintain sterol balance in mice fed a high cholesterol diet
Garrett Anspach, Rupinder Kaur, Isha V. Chauhan, Erika L. Savage, Brittney Poole, Victoria P. Noffsinger, Xiaoming Fu, Zeneng Wang, Clairity Voy, Ryan E. Temel, Scott M. Gordon, Robert Nathaniel Helsley, Gregory A. Graf
This study shows that G5G8-independent mechanisms cannot compensate for G5G8 deficiency in mice fed a high cholesterol diet, leading to sterol accumulation in the liver and plasma.
Journal of Lipid Research · Sep 16, 2025Peer-reviewedPhysiology