Xiaowei Wang

Sequence-specific and programmable catalytic degradation of extracellular microRNAs by membrane-anchored DNA nanomachines

This paper introduces PRIME, a DNA nanomachine that degrades extracellular miRNAs, showing significant depletion and therapeutic effects in cancer models.

Synchronized Latency Reversal and Immune Clearance by a Multifunctional Fusion Protein Enables HIV-1 Reservoir Reduction

This paper develops a fusion protein that reactivates HIV-1 latency and enhances immune clearance, reducing viral reservoirs in HIV-infected individuals and humanized mice.

ORP2 regulates free cholesterol accumulation in hepatocytes during MASH

This study shows that ORP2 prevents free cholesterol accumulation in mouse liver, and its absence leads to severe MASH with cholesterol crystals.

OsWHY1/OsTRXz/OsMORFs complex is essential for RNA modification and early chloroplast development in rice

This study identifies OsWHY1's role in chloroplast development by interacting with OsTRXz and OsMORFs to regulate RNA modification and maintain chloroplast stability.

Involvement of OsS40-14 in ROS and plastid organization related regulatory networks of dark-induced senescence in rice

This study identifies OsS40-14 as a transcription factor regulating ROS and plastid organization during dark-induced senescence in rice, showing its role in macromolecule metabolism and nutrient recycling.

A CRISPR screen reveals a WNT7B-FZD5 signaling circuit as a therapeutic opportunity in pancreatic cancer.

The paper identifies a WNT7B-FZD5 signaling circuit as a therapeutic target in pancreatic cancer using CRISPR screening and validates it with antibodies.

WU-CRISPR: characteristics of functional guide RNAs for the CRISPR/Cas9 system

The paper identifies features of effective CRISPR sgRNAs and develops a tool, WU-CRISPR, for designing them with improved efficiency.