Author

Xiaoxiao Ma

The Hong Kong University of Science and Technology (Guangzhou)Primary ORCID profile (0000-0001-8661-5660 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Xiaoxiao MaiD1 paper · Cleveland Clinic

Biology Disciplines

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Bioengineering· 1 Immunology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:large language model· 1

Frequent Co-Authors

Shiyang You· 2 shared Xianjun Deng· 2 shared An‐Ping ZengiD· 1 shared Arthur K.L. LIN· 1 shared Chenchen HaniD· 1 shared Chentong WangiD· 1 shared Chunjun Zhan· 1 shared Fajie YuaniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioengineering

Shiyang You

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Toward De Novo Protein Design from Natural Language

Fengyuan Dai, Shiyang You, Yudian Zhu, Yuan Gao, Lihao Fu, Xibin Zhou, Jin Su, Chentong Wang, Yuliang Fan, Qingsong Tan, Xiaoxiao Ma, Xianjun Deng, Letong Yu, Hui Qian, Yan He, , Fajie Yuan

This paper introduces Pinal, a foundation model that designs proteins from natural language descriptions, achieving functional alignment and experimental success in four design tasks.

Nature · Oct 21, 2026Peer-reviewedBioengineering

Helminth-remodeled microbial indole-3-lactic acid drives AhR-dependent disease tolerance

Ruohang Sun, Yi Liu, Yue Wang, Nuo Xu, Xiaoxiao Ma, Qingbo Lv, Xiufeng Zhao, Isabelle Vallée, Pascal Boireau, Zeming Wu, M Y Liu, Xiaolei Liu, Xuemin Jin

This study shows helminth infection remodels gut microbiota to produce ILA, which activates AhR to promote immune tolerance and reduce inflammation in viral infections.

bioRxiv · May 8, 2026 · PreprintImmunology

A coupled fluorescence assay for high-throughput screening of polyurethane-degrading enzymes

Liujun YANG, Xianjun DENG, Renju LIU, Jianyang Li, Junyao ZHAI, Xiaoxiao MA, Shiyang YOU, He Qinghao, Arthur K.L. LIN, Zongze Shao, LU Hongyuan

This paper introduces a high-throughput screening assay for polyurethane-degrading enzymes using a synthetic substrate and fluorescence detection to quantify enzymatic activity.

Journal of Hazardous Materials · Feb 1, 2026Peer-reviewedSynthetic Biology