Shiyang You

This paper introduces Pinal, a foundation model that designs proteins from natural language descriptions, achieving functional alignment and experimental success in four design tasks.

This paper introduces AMPHORA, a pathogen-conditioned generator of antimicrobial peptides, showing that incorporating pathogen-specific features improves peptide design and potency.

This paper introduces a high-throughput screening assay for polyurethane-degrading enzymes using a synthetic substrate and fluorescence detection to quantify enzymatic activity.

ProTrek introduces a tri-modal contrastive learning model for protein sequence, structure, and function, achieving significant improvements in speed and accuracy over existing tools.

Evolla, a protein-language model, improves functional inference and discovers novel proteins through natural language queries and benchmarking.