Synaptic endocytic failure drives dopamine deficiency and protein transfer-mediated striatal dopamine-like neuron compensation
Youneng Lin, Ana Caulino‐Rocha, Bandhan Mukherjee, Man Liu, Xiaoxing Cao, Zhen Wang, Chuying Lai, Hua Huang, Zheng Ding, Ira Milošević, Mian Cao
The paper shows that synaptic endocytic failure in dopamine neurons leads to the emergence of dopamine-like neurons through protein transfer, supporting dopamine compensation in early Parkinson's disease.
bioRxiv · May 14, 2025 · PreprintNeuroscience