Zhen Wang

A Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer

This study identifies a stress-lipid kinase axis in NEPC driven by PIKfyve, revealing a synthetic vulnerability between PIKfyve and FASN that can be exploited for therapeutic targeting.

Ground Truth-Based Evaluation of False Discovery Rate and Statistical Power in DIA Proteomics

This study evaluates false discovery rate and statistical power in DIA proteomics using technical replicates and spike-in experiments, revealing discrepancies between nominal and true FDR and showing power dependence on fold change and abundance.

lncRNA-ISM1 Promotes Hepatocellular Carcinoma Progression through RBM10-Mediated Alternative Splicing of ISM1 and Akt-S6-Dependent Glucose Metabolic Reprogramming

This study identifies lncRNA-ISM1 as a driver of hepatocellular carcinoma progression by regulating ISM1 alternative splicing and Akt-S6-dependent glucose metabolism.

CLM-X: A multimodal single-cell foundation model with flexible multi-way Transformer for unified scRNA-seq and scATAC-seq analysis

CLM-X is a multimodal single-cell foundation model that outperforms existing methods in cross-modal translation and perturbation prediction across scRNA-seq and scATAC-seq datasets.

Empagliflozin alleviates doxorubicin-induced cardiotoxicity by suppressing oxidative stress via modulation of the JNK/Nrf2 signaling pathway

This study shows empagliflozin reduces doxorubicin-induced cardiotoxicity by modulating the JNK/Nrf2 pathway and decreasing oxidative stress in mice.

Synaptic endocytic failure drives dopamine deficiency and protein transfer-mediated striatal dopamine-like neuron compensation

The paper shows that synaptic endocytic failure in dopamine neurons leads to the emergence of dopamine-like neurons through protein transfer, supporting dopamine compensation in early Parkinson's disease.

Multi-lineage transcriptional and cell communication signatures define evolving personalized mechanisms that initiate and perpetuate rheumatoid arthritis

The paper identifies shared transcriptional and cell communication signatures in RA patients and at-risk individuals, showing how multiple pathogenic mechanisms contribute to disease initiation and progression.

The first near-complete genome assembly of pig: enabling more accurate genetic research

This paper presents a near-complete pig genome assembly, improving upon the existing reference by closing gaps and enhancing gene prediction, which supports better genetic research and applications.

Waiting for the Perfect Vaccine

The paper models optimal vaccination coverage with low-efficacy vaccines during outbreaks, showing that high coverage may reduce severe outcomes even if it doesn't minimize total infections.

maskNMF: A denoise-sparsen-detect approach for extracting neural signals from dense imaging data

maskNMF improves demixing of dense calcium imaging data by denoising, sparsening, and using constrained non-negative matrix factorization to accurately recover neural activity.

Arginine Methylation Regulates SARS-CoV-2 Nucleocapsid Protein Function and Viral Replication

This study shows that arginine methylation of SARS-CoV-2 N protein by PRMT1 is essential for RNA binding and suppression of stress granules, and inhibiting this methylation reduces viral replication.