Joint protein-DNA language modeling enables prediction and engineering of DNA recognition specificity
Yangfang Xiong, Jiwu Ren, Xiaoxu Wei, Xiaoyu Li, Jiayi Li, Wensheng Wei
This paper introduces PDLMs, protein-DNA language models that jointly represent protein and DNA sequences to predict and engineer DNA recognition specificity.
bioRxiv · Nov 6, 2026 · PreprintBioinformatics