Author

Xiaoyu Li

Fudan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Bo PengiD· 2 shared Li CaoiD· 2 shared Pei OuyangiD· 2 shared Yanxia RaoiD· 2 shared Yuxiao JiniD· 2 shared Baozhi Yang· 1 shared Chi Dang· 1 shared Guozhu NingiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersNeuroscience

Bo PengORCID

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Author profile →

4 papers

Recent·Most cited

Joint protein-DNA language modeling enables prediction and engineering of DNA recognition specificity

Yangfang Xiong, Jiwu Ren, Xiaoxu Wei, Xiaoyu Li, Jiayi Li, Wensheng Wei

This paper introduces PDLMs, protein-DNA language models that jointly represent protein and DNA sequences to predict and engineer DNA recognition specificity.

bioRxiv · Nov 6, 2026 · PreprintBioinformatics

Ligand-specific endothelial Notch signaling coordinates brain pericyte specification and expansion

Huaxing Zi, Chi Dang, Weiyi Sima, Xiaoyu Li, Guozhu Ning, Li Sun, Qiang Wang, Jingjing Zhang

This study identifies ligand-specific endothelial Notch signaling as a mechanism coordinating brain pericyte specification and expansion in zebrafish.

bioRxiv · Oct 9, 2026 · PreprintDevelopmental Biology

In vivo virus-free lineage tracing and live imaging 1 reveal that NeuroD1 does not reprogram microglia into neurons

Xiaoyu Li, Li Y, Yue Cao, Niewen Hu, Baozhi Yang, Pei Ouyang, Yuxiao Jin, Shuai Gao, Li Cao, Bo Peng, Yanxia Rao

The paper shows NeuroD1 does not convert microglia into neurons, instead causing apoptosis, using lineage tracing and single-cell RNA sequencing.

bioRxiv · Aug 27, 2026 · PreprintNeuroscience

Microglia replacement effectively attenuates the disease progress of ALSP in the mouse model and human patient

Jingying Wu, Yafei Wang, Xiaoyu Li, Yuanyuan Cai, Pei Ouyang, Yang He, Mengyuan Zhang, Xinghua Luan, Yuxiao Jin, Taohui Liu, Yuxin Li, Xiao‐Jun Huang, Ying Qing Mao, Yanxia Rao, Li Cao, Bo Peng

This study shows that microglia replacement through bone marrow transplantation halts disease progression in both mouse models and human patients with ALSP.

bioRxiv · Jun 11, 2024 · PreprintNeuroscience