Sustained Relief of Chronic Pain via a Nav1.7_Targeting ASO_siRNA Conjugate
Bin Ren, Chang Yu, Weiqin Yin, Zhuangchuan Yuan, Hongyu Chen, Yicao Liu, Bin Fang, Suyuan Liu, Lianchao Gao, Zhiwei Cao, Qingqing Yu, Xin Qiu, Peixia Yu, Guohao Wang
This paper develops an ASO-siRNA conjugate that provides sustained pain relief by targeting Nav1.7, outperforming individual components and existing drugs in preclinical models.
bioRxiv · Mar 30, 2026 · PreprintNeuroscience