Author

Hongyu Chen

China University of Geosciences (Beijing)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genetics· 1 Microbiology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Bin Fang· 1 shared Bin ReniD· 1 shared Bo WangiD· 1 shared Chang Yu· 1 shared Dan LiiD· 1 shared Guohao WangiD· 1 shared Haina WangiD· 1 shared haonan zhangiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperNeuroscience

Bin Fang

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Author profile →

4 papers

Recent·Most cited

Sustained Relief of Chronic Pain via a Nav1.7_Targeting ASO_siRNA Conjugate

Bin Ren, Chang Yu, Weiqin Yin, Zhuangchuan Yuan, Hongyu Chen, Yicao Liu, Bin Fang, Suyuan Liu, Lianchao Gao, Zhiwei Cao, Qingqing Yu, Xin Qiu, Peixia Yu, Guohao Wang

This paper develops an ASO-siRNA conjugate that provides sustained pain relief by targeting Nav1.7, outperforming individual components and existing drugs in preclinical models.

bioRxiv · Mar 30, 2026 · PreprintNeuroscience

Insights into the spool-like architecture and infectionstrategy of the archaeal virus SEV1

haonan zhang, Haina Wang, Yan Li, Yunxuan Fan, Zhenfeng Zhang, Hongyu Chen, Kai Song, Li Huang, Ping Zhu

This study uses cryo-electron tomography to reveal the spool-like architecture and infection strategies of the archaeal virus SEV1, showing its flexibility and unique assembly process.

Science Advances · Jul 18, 2025Peer-reviewedMicrobiology

Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis

Kaili Du, Hongyu Chen, Zhaonan Pan, Mengli Zhao, Shixue Cheng, Yu Luo, Wenhe Zhang, Dan Li

This study shows that activating TFEB with sulforaphane reduces cholesterol accumulation in NPC1 models by enhancing lysosomal exocytosis and biogenesis.

eLife · Apr 4, 2025Peer-reviewedMolecular Biology

Identification of plant-derived microRNAs in human kidney

Xi Chen, Xishao Xie, Lu Liu, Hongyu Chen, Bo Wang, Zheng Li, Linghui Zeng, Michael Paul Timko, Jianghua Chen, Weiqiang Lin, Longjiang Fan

The paper identifies plant-derived microRNAs in human kidney transplant patients and links three miRNAs to immune rejection.

bioRxiv · Oct 25, 2022 · PreprintGenetics