Atmospheric particulate matter aggravates CNS demyelination via TLR-4/NF-κB-mediated microglia pathogenic activities
Bing Han, Xing Li, Si-Ying Deng, Ze-Qing Ye, Ruo-Song Ai, Xin Deng, Wen Ma, Shun Xiao, Jing-Zhi Wang, Li-Mei Wang, Chong Xie, Yan Zhang, Yan Xu, Yuan Zhang
This study shows that atmospheric particulate matter worsens CNS demyelination by activating TLR-4/NF-κB signaling in microglia, leading to neuroinflammation and myelin injury.
eLife · Feb 23, 2022Peer-reviewedNeuroscience