Yan Xu

NPlasmid-seq: Cas9-encoded terminal signatures enable molecule-level nanopore quality control of vector and IVT-template plasmids

NPlasmid-seq detects sub-percent contamination and sequence heterogeneity in plasmid preparations using Cas9-encoded terminal signatures, revealing structural variants missed by consensus-based methods.

MoTRUST: adaptive semantic protection for mosaic single-cell integration and molecular recovery

MoTRUST integrates mosaic single-cell multi-omics data and recovers missing molecular information, achieving top performance in integration and recovery tasks.

Decoding Lymphangioleiomyomatosis (LAM) Niche Environment via Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics

This study identifies two distinct LAM subtypes and their microenvironmental interactions using multi-omics and spatial transcriptomics, revealing key regulatory networks and potential therapeutic targets.

Immune Evasion, Cell-Cell Fusion, and Spike Stability of the SARS-CoV-2 XEC Variant: Role of Glycosylation Mutations at the N-terminal Domain

This study examines how glycosylation mutations in the NTD of the SARS-CoV-2 XEC variant affect neutralizing antibody responses, cell-cell fusion, and spike stability.

Neutralization and Stability of JN.1-derived LB.1, KP.2.3, KP.3 and KP.3.1.1 Subvariants

This study evaluates neutralization, infectivity, and stability of JN.1-derived SARS-CoV-2 subvariants, finding that DelS31 mutation in the NTD reduces nAb titers, impairs infectivity, and increases spike stability.

Spatial domains identification in spatial transcriptomics by domain knowledge-aware and subspace-enhanced graph contrastive learning

This paper introduces GRAS4T, a graph contrastive learning framework for spatial domain identification in spatial transcriptomics, showing improved performance over existing methods.

Selective Androgen Receptor Modulator Microparticle Formulation Reverses Muscle Hyperalgesia in Mouse Model of Widespread Muscle Pain

A selective androgen receptor modulator microparticle formulation alleviates widespread muscle pain in male and female mice while being non-toxic.

Atmospheric particulate matter aggravates CNS demyelination via TLR-4/NF-κB-mediated microglia pathogenic activities

This study shows that atmospheric particulate matter worsens CNS demyelination by activating TLR-4/NF-κB signaling in microglia, leading to neuroinflammation and myelin injury.

A high-throughput analysis method of microdroplet PCR coupled with fluorescence spectrophotometry

This paper introduces a microdroplet PCR method combined with fluorescence spectrophotometry for qualitative, quantitative, and high-throughput DNA detection, validated using GM maize and foodborne bacteria.

Enabling the democratization of the genomics revolution with a fully integrated web-based bioinformatics platform

The paper introduces a web-based bioinformatics platform to simplify genomics analysis for non-experts by integrating tools and workflows.