Author

Xinping Tan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

Huan CheniD· 2 shared Ye Bu· 2 shared Zhiyong Dai· 2 shared Danlan Qiu· 1 shared Guangping GaoiD· 1 shared Huapeng Li· 1 shared Huapeng LiiD· 1 shared Jingluan HaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMolecular Biology

Huan ChenORCID

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2 papers

Recent·Most cited

Precision DNA Impurity Reduction Approaches for Ultra-Pure rAAV Manufacturing

Jingluan Han, Huan Chen, Xinping Tan, Zhiyong Dai, Ye Bu, Huapeng Li

The paper evaluates DNA impurity reduction strategies in rAAV manufacturing, finding that TelN/TelROL and I-SceI reduce plasmid backbone DNA to 20-40%, CRISPR/Cas9 to 10-20%, and Cre/LoxP eliminates it without affecting vector titers.

bioRxiv · Apr 7, 2026 · PreprintMolecular Biology

Engineering novel AAV capsids by global de-targeting and subsequent muscle-specific tropism in mice and NHPs

Pan Yue, Yujian Zhong, Huan Chen, Youwei Zhang, Zhiyong Dai, Junlin Chen, Keqin Tan, X B Chen, Danlan Qiu, Longxiang Sheng, Xinping Tan, Ying Fan, Ye Bu, Zexin Zhou, Zhiming Yang, , Huapeng Li

The paper develops AAV.eM, a muscle-specific rAAV capsid with reduced off-target transduction, showing efficacy in Duchenne Muscular Dystrophy models and favorable safety in mice and NHPs.

bioRxiv · May 19, 2025 · PreprintBioengineering