Transcriptome-wide mapping reveals a non-canonical RNA-dependent mechanism of platinum cancer drugs
Arun Krishnaraj, Xinrui Wei, Richi Thakral, Weiyi Guo, Siva Bala Subramaniyan, Xiaopei Zhang, Katelyn R. Alley, Anqi Feng, Andrew Hoy, Douglas Kung, Purushottam Babu Tiwari, Aykut Üren, Rodrigo A. Maillard, Victoria J. DeRose, Sreejith J. Nair
The paper identifies cisplatin as an RNA binder and shows its cytotoxicity is partially mediated through RNA binding, revealing a noncanonical mechanism of action.
bioRxiv · Sep 16, 2026 · PreprintMolecular Biology