Xu Li

Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism

This study shows that red light exposure reduces SIRT4 in aged mice, enhancing H3K9ac via fatty acid metabolism and mitigating cellular aging.

Gene III(R) L-Ergothioneine Ameliorates Exercise-Induced Fatigue by Attenuating Oxidative Stress, Inflammation, and Modulating the AMPK/PGC-1α Signaling Pathway

This study shows that Gene III(R) EGT improves exercise performance and reduces fatigue in mice by lowering oxidative stress, inflammation, and activating the AMPK/PGC-1α pathway.

Endolysosomal damage promotes intraluminal protein condensate formation that limits cytosolic leakage

The paper shows that endolysosomal damage leads to intraluminal protein condensates that prevent cytosolic leakage and sequester therapeutic oligonucleotides.

Gene III Ergothioneine ameliorates alcoholic fatty liver disease: A dual strategy of accelerated ethanol elimination and reducing oxidative stress

This study shows Gene III Ergothioneine reduces alcoholic fatty liver disease by speeding up ethanol elimination and lowering oxidative stress.

Ergothioneine: Evaluation of a Novel Antioxidant for Targeting Ocular Oxidative Stress

This paper evaluates L-Ergothioneine as a novel antioxidant for ocular diseases, showing superior radical scavenging, stability, ocular safety, and fundus delivery via topical application.

Topological Skeletonization and Tree-Summarization of Neurons Using Discrete Morse Theory

The paper introduces a method using Discrete Morse Theory to extract and summarize neuronal tree structures from volumetric brain images, providing a more informative summary than traditional connectivity matrices.