Yang Liu

Postsynaptic TAK1-GluN2B axis supports hippocampal synaptic integrity and cognitive function during aging

This study identifies a postsynaptic TAK1-GluN2B signaling axis that maintains synaptic integrity and cognitive function, with reduced TAK1 levels contributing to age-related hippocampal decline.

Phenotype-cloud reorganization shapes cancer progression and therapeutic adaptation

This study identifies phenotype-cloud transitions as an organizational feature of cancer progression and therapeutic adaptation, showing how tumours reorganize phenotypic states during progression and treatment.

LongVerse: verified AI agents for Nanopore and PacBio DNA methylation analysis

LongVerse uses AI agents to generate haplotype-resolved DNA methylation calls from Nanopore and PacBio reads, achieving high agreement with bisulfite sequencing and reducing errors compared to existing methods.

A split-control criterion for few-shot adaptation in single-cell perturbation prediction

This paper introduces SafeDelta, a split-control criterion for few-shot adaptation in single-cell perturbation prediction, showing it improves reproducibility and identifies biological programs.

Grow2Fold: mapping heterogeneous developmental growth to human brain folding

Grow2Fold models brain folding by integrating imaging data with mechanical simulations to show differential growth drives cortical folding patterns.

Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism

This study shows that red light exposure reduces SIRT4 in aged mice, enhancing H3K9ac via fatty acid metabolism and mitigating cellular aging.

The uplift of the Qinghai-Tibetan Plateau reshaped genome architecture and diversification of Asian torrent catfishes

This study shows how tectonic uplift influenced genome structure and diversification in Asian torrent catfishes through chromosomal rearrangements and evolutionary processes.

Scaling genome annotation across the eukaryotic tree of life with OrionGeno

OrionGeno annotates over 5,300 eukaryotic genomes using a phylogeny-aware deep learning model, outperforming existing methods in gene and protein structure prediction.

Dietary sugar type determines the response to protein restriction in females, but not males

The paper shows that in female mice, carbohydrate quality affects metabolic and neurological responses to low protein diets, but not in males.

Immune-enriched fibrovascular cores establish localized immunosuppressive niches in papillary malignancies

The paper identifies immune-enriched fibrovascular cores in papillary tumors that create immunosuppressive niches through PAI-1-driven macrophage fusion.

Continuous target-specific mutagenesis and rapid gene evolution by diversity-generating retroelements in Escherichia coli

This paper demonstrates a system using DGRs in E. coli to perform continuous, targeted mutagenesis of genes, enabling rapid evolution of specific sequences.

Ribonucleotide Reductase Inhibition Overcomes FLT3 Inhibitor Resistance in Acute Myeloid Leukemia

This paper identifies RNR inhibition as a strategy to overcome FLT3 inhibitor resistance in FLT3ITD+ AML by reversing resistance mechanisms and enhancing therapeutic efficacy.

Short-term methionine starvation induces de novo diurnal oscillations of hepatic m6A RNA methylation

This study shows that short-term methionine starvation causes new daily rhythms in m6A RNA methylation in mouse liver, linking methionine metabolism to circadian regulation.

Aging restricts colorectal tumor growth by epigenetically silencing developmental gene programs

This study shows aging restricts colorectal tumor growth by epigenetically silencing developmental gene programs, with implications for early-onset colorectal cancer.

A Facile and Versatile Technique for Creating Antifibrotic Coatings on Biomedical Implants

This paper develops a versatile method for creating antifibrotic coatings on biomedical implants, showing a 60% reduction in fibrotic capsule thickness in mice.

Methionine Deprivation-induced Reprogramming of Hepatic Rhythms Is Mediated by Glucocorticoid Receptor

This study shows that methionine deprivation in mice reprograms hepatic circadian rhythms via glucocorticoid receptor mechanisms.

Integration of spatial single-cell proteomics and spatial metabolomics reveals tumor microenvironment predictive of immunotherapy response in mucosal melanoma

Longitudinal Single-Cell RNA-seq Profiling of Lung Cell Phenotypes, Signaling, and Cross-talk During Fibrosis Resolution

The paper uses longitudinal single-cell RNA-seq to study lung fibrosis resolution, identifying pro- and anti-fibrotic pathways and cellular interactions during recovery.

Female resistance to the metabolic benefits of protein restriction is reversed by ovariectomy in mice

This study shows that ovariectomy in female mice enhances their metabolic response to a low protein diet, aligning it with males, while castration has little effect on males.

Cross-Species Multi-Omics Profiling Identifies Conserved Activated Valvular Interstitial Cell Population Driving Myxomatous Mitral Valve Degeneration

The paper identifies a conserved activated valvular interstitial cell population across species and disease types that drives myxomatous mitral valve degeneration.

Automated Cyclic Super-Resolution Microscopy for Nanoscale Protein Mapping

The paper introduces CycSTORM, an automated cyclic (d)STORM platform for multiplexed nanoscale protein mapping in single cells, achieving sub-5 nm precision and reducing signal variability across imaging cycles.

The Protective Role of Intestinal Alkaline Phosphatase in Inflammatory Bowel Disease-Associated Non-Alcoholic Fatty Liver Disease

This study investigates the role of intestinal alkaline phosphatase (IAP) in mitigating IBD-associated NAFLD, finding that IAP supplementation improves gut barrier function and microbiota stability through a TLR4-dependent mechanism.

Germline genetic risk converges through intercellular crosstalk in tumor microenvironment

The paper integrates genetic and transcriptomic data to show that germline variants influence tumor microenvironment cell interactions and prognosis in nasopharyngeal carcinoma.

On the Utility of Virtual Staining for Downstream Applications as it relates to Task Network Capacity

This study evaluates how virtual staining affects downstream tasks like segmentation and classification, showing its effectiveness depends on the task network's capacity.

Epigenomic Heterogeneity of Non-Functional Pancreatic Neuroendocrine Tumors Uncovered by Single nucleus and Spatial ATAC Profiling

This study uses single-nucleus and spatial ATAC-seq to uncover epigenomic heterogeneity and spatial niches in non-functional pancreatic neuroendocrine tumors.

Sensitive, non-invasive detection of chronic wasting disease in wild and captive white-tailed deer using fecal volatile profiling

This study detects CWD in deer using fecal VOCs, identifying specific compounds that distinguish infected from uninfected animals in both captive and wild populations.

Small molecule oxybutynin rescues proliferative capacity of complex III-defective MPCs

This study shows that oxybutynin rescues proliferative capacity and metabolic function in Complex III-defective mitochondrial progenitor cells.

Overcoming breeding constraints in polyploid oat from evolutionary insights

This study uses genome and transcriptomic analyses of oat species to show that polyploidy creates functional redundancy, buffering mutations but hindering beneficial allele fixation, and proposes breeding strategies to overcome these challenges.

Interwoven DNA-MOF crystals for multi-millennial data storage

This paper introduces DNA-MOF crystals for long-term data storage, achieving high density and stability over 24,000 years.

Diverse ancestral brainstem noradrenergic neuron activity across species and biological factors

This study analyzes LC neuron firing patterns across species and biological factors, revealing diverse activity patterns and subregions enriched for specific factors and disease models.