Author

Xudong Wang

University of South Florida

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Biophysics· 2 Bioinformatics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Libin YeiD· 2 shared Sun WenkaiiD· 2 shared C Zhang· 1 shared Cheng ZhangiD· 1 shared Cheng ZhuiD· 1 shared Chengyun ZhangiD· 1 shared Hongliang DuaniD· 1 shared Huimin Pang· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiophysics

Libin YeORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An Excelled Trifluorinated Probe for GPCR Conformational Quantification

Xudong Wang, Yunlong Cao, Wenjei Zhao, Sun Wenkai, Trang Ma, Yongbo Zhang, Libin Ye

This paper introduces a novel 19F-labeled probe, BTMB, for studying GPCR conformational dynamics and demonstrates its advantages over existing probes through molecular dynamics simulations.

bioRxiv · Sep 24, 2026 · PreprintBiophysics

Ligand-Specified Signaling Efficacy Defined by Unique Transitions in G Protein Conformations

Xudong Wang, Sun Wenkai, Nathaniel Hays, Pangche Wang, Cheng Zhang, C Zhang, Libin Ye

This study quantifies Gs protein conformational transitions in response to different ligands, revealing ligand-specific dynamics that determine GPCR signaling efficacy.

bioRxiv · Jul 25, 2026 · PreprintBiophysics

HighPlay：Cyclic Peptide Sequence Design Based on Reinforcement Learning and Protein Structure Prediction

Huitian Lin, Cheng Zhu, Tianfeng Shang, Ning Zhu, Kang Lin, Chengyun Zhang, Xiang Shao, Xudong Wang, Hongliang Duan

HighPlay uses reinforcement learning and protein structure prediction to design cyclic peptides with good binding affinity, validated through molecular dynamics simulation and experimental testing.

Journal of Medicinal Chemistry · May 23, 2025Peer-reviewedBioinformatics

Hv1 channel supports insulin secretion in pancreatic β cells through calcium entry, depolarization and intracellular pH regulation

Huimin Pang, Xudong Wang, Wang Xi, Qing Zhao, Shangrong Zhang, Jiwei Qin, Jili Lv, Yongzhe Che, Weiyan Zuo, Shu Jie Li

bioRxiv · Sep 5, 2018 · PreprintCell Biology