Achieving near single-molecule sensitivity in separation-free protein detection using engineered kinetic proofreading
Feng Xuan, Tsz Wing Fan, Xi Chen, Yu Wang, WonHee Kim, Wenjing Jiang, Jidong Tan, Xue Jiang, Yu Zhang, Pia Kivisäkk, Bruno L. Hammerschlag, Oscar L. López, Ann D. Cohen, Xuemei Zeng, Taraneh E Atri, , Peng Yin
This paper introduces SPEAR, a separation-free protein detection method that achieves sub-100-molecule sensitivity using engineered kinetic proofreading, outperforming existing methods for Alzheimer's and SARS-CoV-2 biomarkers.
bioRxiv · Oct 7, 2026 · PreprintBioengineering