BioengineeringbioRxivPreprint
Achieving near single-molecule sensitivity in separation-free protein detection using engineered kinetic proofreading
Feng Xuan, Tsz Wing Fan, Xi Chen…·Peng Yin
This paper introduces SPEAR, a separation-free protein detection method that achieves sub-100-molecule sensitivity using engineered kinetic proofreading, outperforming existing methods for Alzheimer's and SARS-CoV-2 biomarkers.
DOI 10.64898/2026.10.05.756571