Xue Li

Reversible, Sexually Dimorphic Sympathetic Aging: Distal Axon Withdrawal Shaped by Prepubertal Gonadal Influences

This study shows that sympathetic aging is reversible and sexually dimorphic, with male mice showing greater denervation due to gonadal influences and target environment changes.

A Multidimensional Analysis of the Bimodal Piperaquine Response in Plasmodium falciparum

The paper investigates the bimodal piperaquine response in Plasmodium falciparum by analyzing metabolic, transcriptional, and molecular dynamics data to identify the role of plasmepsin II/III copy number and pfcrt mutations.

Fast in vivo deep-tissue 3D imaging with selective-illumination NIR-II light-field microscopy and aberration-corrected implicit neural representation

This paper introduces a fast 3D in vivo imaging technique using NIR-II light-field microscopy with aberration correction, enabling high-speed visualization of biological processes in mice.

scIsoAgent enables autonomous isoform-resolved characterization and sequence-informed interpretation of long-read single-cell transcriptomes

scIsoAgent improves long-read single-cell RNA-seq analysis by creating reproducible, isoform-resolved workflows and linking sequence data to functional hypotheses.

A Cross-tissue Temporal Multi-omics Atlas Reveals the Molecular Architecture of Pressure Injury

This study creates a cross-tissue temporal multi-omics atlas of pressure injury in rats, revealing stage-specific molecular programs and their tissue-specific adaptations.

Blood biomarkers and breed genetics of aging in pet dogs

This study identifies blood biomarkers and genetic factors associated with aging in dogs using genomic and phenotypic data from 7,627 dogs.

SARS-CoV-2 NSP14 inhibitor exhibits potent antiviral activity and reverses NSP14-driven host modulation

This paper identifies and characterizes C10, a potent SARS-CoV-2 NSP14 inhibitor with antiviral activity and host transcriptome modulation effects.

Subgenual Anterior Cingulate Cortex Functional Connectivity Abnormalities in Depression: Insights from Brain Imaging Big Data and Precision-Guided Personalized Intervention via Transcranial Magnetic Stimulation

The paper identifies sgACC functional connectivity abnormalities in depression using large-scale brain imaging data and develops an individualized TMS targeting algorithm to improve treatment outcomes.

MalKinID: A Likelihood-Based Model for Identifying Malaria Parasite Genealogical Relationships Using Identity-by-Descent

MalKinID identifies malaria parasite genealogical relationships using IBD proportions and segment distributions, showing high accuracy in outcrossed importations but reduced performance in inbreeding scenarios.

Integrating gene annotation with orthology inference at scale

TOGA integrates gene annotation and orthology inference across hundreds of genomes, improving ortholog detection and creating large comparative gene resources.

Simultaneous Profiling of Host Expression and Microbial Abundance by Spatial Meta-Transcriptome Sequencing

The paper develops a pipeline to profile both host expression and microbial abundance from spatial transcriptomic data, demonstrating host-microbe interactions and method efficiency.

Spatial Meta-transcriptomes of human and murine intestines

The paper develops a pipeline to analyze spatial transcriptomic data for microbial sequences, validates it on human and murine intestinal datasets, and presents initial biological insights.