Y. Even

The parathyroid hormone-dependent activation of osteoblasts enhances hematopoietic stem cell migration and reduces their engraftment abilities

This study shows that PTH-dependent osteoblast activation increases LT-HSC migration but reduces their engraftment ability in irradiated bone marrow.

After migration into blood circulation, hematopoietic stem cells can stably self-renew and maintain bone marrow while being skewed toward myeloid lineage when submitted to serial transplantation.

This study shows that migratory HSCs can self-renew and maintain BM but have reduced lymphoid reconstitution in serial transplants.