Cancer BiologybioRxiv
Antitumor activity of a lectibody targeting cancer-associated high-mannose glycans
Y. J. Oh, M. Dent, A. R. Freels…·N. Matoba
This study demonstrates that AvFc, a lectibody targeting high-mannose glycans, inhibits cancer cell migration and tumor growth in mice by blocking EGFR and IGF1R activation.
DOI 10.1016/j.ymthe.2022.01.030