S. H. Kim

The paper identifies a hidden oxidative damage pathway in proteins through O2 confinement and photoexcitation, bypassing antioxidant defenses.

The paper investigates high cell density physiology in Escherichia coli, revealing a trade-off between resistance and persistence through transcriptional analysis and machine learning.

This study uses CRISPR/Cas9 RNP to edit regulatory DNA elements in human islet cells, revealing their role in diabetes risk and β cell function.

This study develops iMethyl, a method to estimate genomic hypomethylation from cell-free DNA to predict responses to immune checkpoint blockade in cancer patients.

The paper introduces iMAX FRET, a single-molecule method for structural analysis that captures 3D biomolecular structures and conformational changes through FRET and geometrical reconstruction.

This paper introduces a method to map amino acid positions and post-translational modifications in single protein molecules with sub-nanometer resolution using FRET-based single-molecule protein fingerprinting.

This paper identifies mutations improving stress tolerance in E. coli for melatonin production using a data-driven approach integrating adaptive evolution data and multi-omics analysis.

This paper introduces TCIPs, molecules that activate cell death by rewiring cancer drivers, showing efficacy against DLBCL and potential for broader therapeutic applications.

This study evaluates MIT-001's antiviral activity against SARS-CoV-2 and zoonotic viruses in vitro, showing inhibition of viral replication and restoration of antioxidant gene expression.

This paper demonstrates a single-cell electrochemical aptasensor array using nanopillar technology and redox-labelled aptamers for detecting EpCAM-expressing cells, enabling early cancer diagnosis.

This study shows that de novo fatty-acid synthesis via ACC1 prevents iNKT cell death and promotes their pathogenic roles in allergic asthma.

The paper identifies hyperosmotic stress-responsive genes in CHO cells using CRISPR/Cas9 screening and validates their role in stress resistance and protein production.

This paper demonstrates that silicon chambers improve droplet imaging and incubation by enhancing optical, thermal, and mechanical properties compared to PDMS.

This paper introduces a DNA-based chemical neuron that mimics cold temperature sensing by biological neurons through spiking chemical activity and mathematical similarity to a cold nociceptive model.

This study identifies Anoctamin 9 as essential for mammalian olfaction, showing its role in amplifying olfactory signals and linking its downregulation to Covid-19-associated anosmia.

This study identifies distinct immune and malignant cell phenotypes in ovarian cancer linked to specific mutational processes and anatomic sites.

This paper describes a course module that teaches protein structure fundamentals through enzyme discovery research, using comparative analysis of protease structures from different organisms.

This paper presents a data-driven workflow to design microbial strains using aggregated ALE mutational data, revealing gene-centric mutations that significantly alter cellular states.

The paper analyzes structural genomic variations in cancer cells to understand how mutational processes influence cell-to-cell genomic diversity and tumor evolution.

This study uses AcePET to visualize tumor boundaries and reactive astrocytes in GBM, showing that targeting MCT1 improves survival by enabling complete resection of cancer stem cells.

The paper identifies α1-COP as a negative regulator of callose accumulation by modulating sphingolipid enzyme translocation in Arabidopsis.

This study identifies CHRM1 as a druggable melanoma target influenced by genetic variation in DOPA production, showing DOPA inhibits CHRM1 to suppress melanoma proliferation.

This study encodes multiple virtual signals in DNA barcodes using single-molecule FRET, enabling the differentiation of six barcodes without sequence exchange.

This study identifies TRAF6 and TAK1 as mediators of SAMHD1's suppression of NF-κB activation and HIV-1 infection.

This paper introduces FRET X, a method to measure multiple FRET pairs in single molecules with sub-nanometer resolution by using DNA strand exchange.

This study investigates how MFG-E8 signaling contributes to age-related arterial damage, showing that its deficiency reduces elastolysis, fibrosis, and calcification in mice.

FRETboard is a semi-supervised tool for classifying FRET traces, improving efficiency and accuracy compared to manual methods and existing software.

This paper develops dual-mechanism ER inhibitors that use two distinct targeting moieties to suppress ER activity in breast cancer cells and resistance models.

This study shows that LFA-1 signaling, but not VLA-4, drives cytoskeletal changes enabling T cells to migrate upstream against shear flow.

This study identifies METTL18 as an actin histidine methyltransferase that enhances breast cancer metastasis by promoting actin polymerization and Src activation.