BiochemistrybioRxivPreprint
O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology
A. T. Balana, A.-L. Mahul-Mellier, B. A. Nguyen…·M. R. Pratt
This study shows that O-GlcNAc modification of α-Synuclein leads to amyloid fibrils with reduced seeding activity and pathology in Parkinson's disease models.
DOI 10.1101/2023.03.07.531573