Author

A. Javed

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. Ahmad· 1 shared A. Donia· 1 shared A. M. E. Cassaignau· 1 shared A. M. J. J. Bonvin· 1 shared A. Oleksy· 1 shared A. T. Balana· 1 shared A.-L. Mahul-Mellier· 1 shared B. A. Nguyen· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. Ahmad

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology

A. T. Balana, A.-L. Mahul-Mellier, B. A. Nguyen, M. Horvath, A. Javed, E. R. Hard, Y. Jasiqi, P. Singh, S. Afrin, R. Pedretti, V. Singh, V. M.-Y. Lee, K. C. Luk, L. Saelices, H. A. Lashuel, M. R. Pratt

This study shows that O-GlcNAc modification of α-Synuclein leads to amyloid fibrils with reduced seeding activity and pathology in Parkinson's disease models.

bioRxiv · Mar 7, 2023 · PreprintBiochemistry

A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance

F. van der Krift, D. W. Zijlmans, R. Shukla, A. Javed, P. I. Koukos, L. L. E. Schwarz, E. P. M. Timmermans-Sprang, P. E. M. Maas, D. Gahtory, M. van den Nieuwboer, J. A. Mol, G. J. Strous, A. M. J. J. Bonvin, E. J. A. Veldhuizen, M. van der Stelt, , M. M. Maurice

This study identifies a novel antifolate, C1, that overcomes methotrexate resistance by targeting FPGS-deficient cells through DHFR inhibition.

bioRxiv · Feb 26, 2023Biochemistry

Integration of RT-LAMP and Microfluidic Technology for Detection of SARS-CoV-2 in Wastewater as an Advanced Point-of-care Platform

A. Donia, M. F. Shahid, S.-u. Hassan, A. Ahmad, A. Javed, M. Nawaz, T. Yaqub, H. Bokhari

This study evaluates RT-LAMP and RT-qPCR for SARS-CoV-2 detection in wastewater samples using microfluidic chips, finding N gene as a better surrogate marker.

bioRxiv · Aug 18, 2021Microbiology

Mechanochemical control of epidermal stem cell divisions by B-plexins

C. Jiang, A. Javed, L. Kaiser, M. M. Nava, D. Zhao, D. T. Brandt, J. Fernandez-Baldovinos, L. Zhou, C. Hoess, K. Sawmynaden, A. Oleksy, D. Matthews, L. S. Weinstein, H.-J. Groene, C. M. Niessen, , T. Worzfeld

This study identifies B-plexins as critical for mechanosensing in epidermal stem cells, linking mechanical feedback to cell division control during development and in cancer.

bioRxiv · Apr 30, 2020Cell Biology

Visualising nascent chain dynamics at the ribosome exit tunnel by cryo-electron microscopy

A. Javed, T. Wlodarski, A. M. E. Cassaignau, L. Cabrita, J. Christodoulou, E. V. Orlova

This study uses cryo-EM to visualize nascent chain dynamics at the ribosome exit tunnel, revealing distinct pathways and ribosomal interactions that influence protein folding.

bioRxiv · Dec 16, 2019 · PreprintBiophysics