H. A. Lashuel

This paper introduces LINA, a deep learning method for label-free identification of protein aggregates in living cells, showing that shorter polyglutamine repeats lead to larger aggregates.

This study shows that O-GlcNAc modification of α-Synuclein leads to amyloid fibrils with reduced seeding activity and pathology in Parkinson's disease models.

This study investigates how PTMs in Nt17 of mutant Httex1 affect aggregation, showing that oxM8 delays aggregation and that combinations with AcK6 inhibit fibrillization, with structural insights from spectroscopy and simulations.

This paper introduces a method to produce site-specifically phosphorylated Httex1 proteins using novel kinases and SUMO-fusion purification, enabling further study of phosphorylation's role in Httex1 function.

This study investigates how calcium-induced conformational changes in monomeric alpha-synuclein affect N-terminus exposure and aggregation propensity, identifying sequence-specific conformational differences as key factors.