Whole genome doubling confers unique genetic vulnerabilities on tumor cells
R. J. Quinton, A. Didomizio, M. A. Vittoria, C. J. Ticas, S. Patel, Y. Koga, K. Kotynkova, J. Vakhshoorzadeh, N. Hermance, T. S. Kuroda, N. Parulekar, A. M. Taylor, A. L. Manning, J. D. Campbell, N. J. Ganem
The paper identifies genetic vulnerabilities in WGD+ tumor cells and shows that KIF18A is specifically required for their viability.
bioRxiv · Jun 18, 2020Cancer Biology