Author

A. L. Manning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Research Focus:cancer & tumor microenvironment· 4 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

N. M. Hermance· 3 shared M. A. Vittoria· 2 shared N. Hermance· 2 shared N. J. Ganem· 2 shared R. J. Quinton· 2 shared A. Didomizio· 1 shared A. M. Taylor· 1 shared B. Navarro-Serer· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

N. M. Hermance

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

RB loss sensitizes cells to replication-associated DNA damage by PARP inhibition

L. G. Zamalloa, M. M. Pruitt, N. M. Hermance, H. Gali, R. L. Flynn, A. L. Manning

This study shows that RB loss increases DNA damage in cancer cells by promoting PARylation, and PARP inhibition sensitizes these cells to replication stress and reduced viability.

bioRxiv · Mar 25, 2023 · PreprintCell Biology

Suppression of chromosome instability limits acquired drug resistance

E. A. Crowley, N. M. Hermance, C. P. Herlihy, A. L. Manning

This study shows that suppressing chromosome instability reduces acquired drug resistance in non-small cell lung cancer by altering molecular mechanisms, without affecting tumor growth.

bioRxiv · Jul 10, 2020Cancer Biology

Whole genome doubling confers unique genetic vulnerabilities on tumor cells

R. J. Quinton, A. Didomizio, M. A. Vittoria, C. J. Ticas, S. Patel, Y. Koga, K. Kotynkova, J. Vakhshoorzadeh, N. Hermance, T. S. Kuroda, N. Parulekar, A. M. Taylor, A. L. Manning, J. D. Campbell, N. J. Ganem

The paper identifies genetic vulnerabilities in WGD+ tumor cells and shows that KIF18A is specifically required for their viability.

bioRxiv · Jun 18, 2020Cancer Biology

Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes

B. Navarro-Serer, E. P. Childers, N. M. Hermance, D. Mercadante, A. L. Manning

This study shows Aurora A inhibition disrupts spindle pole clustering in cells with supernumerary centrosomes, leading to mitotic catastrophe and aneuploid daughter cells.

bioRxiv · Feb 2, 2019Cancer Biology

Identification of STK25 as a direct activator of LATS signaling

S. Lim, N. Hermance, T. Mudianto, H. Mustaly, I. P. M. Mauricio, M. A. Vittoria, R. J. Quinton, B. W. Howell, H. Cornils, A. L. Manning, N. J. Ganem

This study identifies STK25 as a novel activator of Hippo signaling by directly phosphorylating LATS, and shows its deletion is common in human cancers.

bioRxiv · Oct 1, 2018Cell Biology