S. Patel

EMMPRIN confers metabolic advantage for monocytes and macrophages to promote disease in a model of multiple sclerosis

This study shows that EMMPRIN promotes pro-inflammatory metabolism in monocytes/macrophages, worsening multiple sclerosis, and its deletion reduces disease severity.

Macrophage Phagocytic Impairment is associated with Dysbiosis of the Respiratory Microbiome in Frail older adults

This study finds that frail older adults have impaired macrophage phagocytosis and a less diverse respiratory microbiome, which may be linked to PPARγ pathway dysfunction.

Enhanced MC1R-signalling and pH modulation facilitate melanogenesis within late endosomes of BLOC-1-deficient melanocytes

This study shows that BLOC-1-deficient melanocytes can produce melanin in late endosomes/lysosomes through pH modulation and enhanced MC1R-signalling.

Multiomics unveils extracellular vesicle-driven mechanisms of endothelial communication in human carotid atherosclerosis

This study identifies EV-driven endothelial communication in human carotid atherosclerosis, showing increased angiogenic activity in symptomatic plaques.

Targeted isolation of bacteria with potential to competitively exclude Staphylococcus aureus in the upper respiratory tract of pigs

The paper identifies Lactococcus lactis strains that inhibit livestock-associated Staphylococcus aureus in pig nasal microbiomes through sequencing-guided isolation and in vitro testing.

Eco-evolutionary dynamics of anthelmintic resistance in soil-transmitted helminths

The paper develops an eco-evolutionary model to study anthelmintic resistance spread in helminths, finding that life cycle parameters influence resistance spread rates across species.

The developing pig respiratory microbiome harbours strains antagonistic to common respiratory pathogens

This study examines the longitudinal development of the piglet nasal microbiome and identifies microbial interactions that could help control respiratory pathogens.

A niche-adapted brain microbiome in salmonids at homeostasis

The paper identifies a resident bacterial community in the brains of healthy salmonids and shows its relationship to gut and blood microbiomes, with adaptations for brain colonization.

Linked regulation of genome integrity and senescence-associated inflammation by p53

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesity

This paper shows that inhibiting BTK in adipose tissue macrophages enhances OxPhos and shifts macrophages to an M2-like state, reducing inflammation and improving metabolic outcomes in obesity.

Colchicine promotes atherosclerotic plaque stability independently of inflammation

This study shows colchicine stabilizes atherosclerotic plaques by converting harmful SMC-derived cells into protective myofibroblast-like cells, independent of its anti-inflammatory effects.

TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2

The paper shows Omicron SARS-CoV-2 lineages rely on ACE2 without TMPRSS2 complexes for entry, due to changes in the ACE2 Collectrin-Like Domain affecting TMPRSS2 activation.

PIEZO1 force sensing controls global lipid homeostasis

This study shows that endothelial PIEZO1 force sensing regulates lipid homeostasis by affecting cholesterol metabolism and excretion, with implications for hyperlipidaemia.

Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin (ELGA) reveal functional IP3 receptors

The paper uses a modified aequorin probe to measure Ca2+ in endo-lysosomes, revealing IP3-sensitive Ca2+ stores and functional IP3 receptors in this compartment.

Inosine Induces Stemness Features in CAR T cells and Enhances Potency

This study shows that inosine enhances CAR T cell stemness and function by modulating metabolism and epigenetics, leading to improved anti-tumor potency.

Development of a human glioblastoma model using humanized DRAG mice for immunotherapy

This study develops a humanized DRAG mouse model to test GBM immunotherapy, showing anti-PD-1 antibodies reduce immunosuppressive cells in xenografted tumors.

Bacteriophage therapy for the treatment of Mycobacterium tuberculosis infections in humanized mice

This study tests three bacteriophages against Mtb and finds that DS6A effectively kills Mtb in culture and infected macrophages, improving survival and reducing bacterial load in humanized mice.

Innate immune signaling drives late cardiac toxicity following DNA damaging cancer therapies

This study identifies cGAS-STING signaling as a driver of late cardiac toxicity after DNA-damaging cancer therapies and shows that targeting this pathway can mitigate cardiotoxicity.

Improved Neutralization of Omicron BA.4/5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent BA.4/5 Vaccine

This study compares the neutralizing antibody responses induced by monovalent and bivalent BA.4/5 vaccines against multiple Omicron sublineages in individuals over 55 years old, finding the bivalent vaccine elicits stronger neutralization.

The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus

SLIT2, a neuro-repellent, enhances neutrophil antibacterial activity against S. aureus by boosting reactive oxygen species production and granule exocytosis, improving infection clearance.

Loss of Mfn1 but not Mfn2 enhances adipogenesis

The paper shows that loss of Mfn1 promotes adipogenesis in cultured cells, while loss of Mfn2 does not, indicating distinct roles for Mfn1 and Mfn2 in adipocyte differentiation.

Developing Novel Biologicals with Multiple Modes of Action (BM) to Combat the EarlyBlight Disease in Tomato (Solanum lycopersicum), Potato (Solanum tuberosum), and BellPepper (Capsicum annuum)

This study develops biological fungicides with multiple modes of action to combat early blight in tomato, potato, and bell pepper, finding formulations 2, 3, and 3 most effective for each crop.

Targeting IRS-1/2 in uveal melanoma inhibits in vitro cell growth, survival and migration, and in vivo tumor growth.

This study shows that NT157, an IRS-1/2 inhibitor, reduces uveal melanoma cell growth, survival, migration, and tumor growth in vivo.

Type 1 interferon perturbates clonal competition by reshaping human blood development

The paper investigates how type 1 interferon affects clonal competition in human blood development by altering HSC differentiation states and clonal fitness.

A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion

This study uses a mouse model to show that a MFN2 mutation causes adipose-specific mitochondrial stress and reduced leptin secretion, linking mitochondrial dysfunction to metabolic disease.

A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability

The paper constructs a structural dendrogram of actinobacteriophage major capsid proteins to explore the evolution of capsid stability using cryo-EM, phylogenetic analysis, and AlphaFold predictions.

Melanoma cells appropriate pericyte:endothelial cell crosstalk during perivascular invasion in the brain

This study identifies how melanoma cells use pericyte:endothelial cell signaling during brain invasion, showing that Sox9hi mesenchymal cells use Snail1-dependent mechanisms while Sox10hi cells form clusters.

Salivary exosomal miR-1307-5p predicts disease aggressiveness and poor prognosis in oral squamous cell carcinoma patients

This study identifies miR-1307-5p in salivary exosomes as a prognostic marker for poor survival and disease aggressiveness in oral squamous cell carcinoma.

Restoration of beta-GC trafficking improves the lysosome function in Gaucher disease

This study identifies phosphatases that modulate beta-GC trafficking and lysosome function in Gaucher disease, suggesting a therapeutic strategy.

Endogenous GDF15 and FGF21 additively alleviate hepatic steatosis and insulin resistance in obese mice.

This study shows that GDF15 and FGF21, secreted by the liver in obese mice, reduce hepatic steatosis and insulin resistance when both are active.