Replicative aging impedes stress-induced assembly of a key human protein disaggregase
Y. Mathangasinghe, N. Alberts, C. J. Rosado, D. Cox, N. L. Payne, A. R. Ormsby, K. M. Alp, R. Sakson, S. Uthishtran, T. Ruppert, S. Arumugam, D. M. Hatters, H. H. Kampinga, N. B. Nillegoda
This study identifies a stress-induced trimeric protein disaggregase in human cells that collapses during replicative aging, contributing to pathophysiological consequences.
bioRxiv · Jun 25, 2022 · PreprintCell Biology