Comprehensive, high-resolution binding energy landscapes reveal context dependencies of transcription factor binding
D. D. Le, T. C. Shimko, A. K. Aditham, A. M. Keys, Y. Orenstein, P. Fordyce
The paper measures TF-DNA binding energies for yeast TFs using a novel sequencing assay and finds that flanking mutations significantly affect binding energy, challenging current site definitions.
bioRxiv · Sep 26, 2017Biophysics