Multiple acyl-CoA thioesterases occupy distinct functional niches within the mitochondrial matrix
C. Bekeova, L. Anderson-Pullinger, K. Boye, F. Boos, Y. Sharpadskaya, J. M. Herrmann, E. L. Seifert
The paper identifies distinct functional roles of mitochondrial Acot enzymes based on substrate specificity and CoA inhibition, revealing their roles in regulating beta-oxidation and preventing lipotoxicity.
bioRxiv · Jul 16, 2019 · PreprintBiochemistry