Author

E. L. Seifert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. Bekeova· 4 shared L. Anderson-Pullinger· 2 shared N. W. Snyder· 2 shared A. Cardenas· 1 shared A. Higgins-Chen· 1 shared A. Monzel· 1 shared A. Sivaramakrishnan· 1 shared A. Towheed· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBiochemistry

C. Bekeova

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Acyl-CoA thioesterase-2 facilitates beta-oxidation in glycolytic skeletal muscle in a lipid supply dependent manner

C. Bekeova, J. I. Han, H. Xu, E. Kerr, B. Blackburne, S. C. Lynch, C. Mesaros, M. Murgia, R. Vadigepalli, J. Beld, R. Leonardi, N. W. Snyder, E. L. Seifert

This study shows ACOT2 regulates acyl-CoA levels in glycolytic muscle, promoting β-oxidation when lipid supply is low but causing lipid accumulation and poor glucose homeostasis when lipid supply is high.

bioRxiv · Jun 27, 2023 · PreprintBiochemistry

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

G. Sturm, K. R. Karan, A. Monzel, B. S. Santhanham, T. Taivassalo, C. Bris, S. A. Duplaga, M. Cross, A. Towheed, A. Higgins-Chen, M. J. McManus, A. Cardenas, J. Lin, E. S. Epel, S. Rahman, , M. Picard

The paper shows that OxPhos dysfunction leads to hypermetabolism and reduced lifespan in cells and mitochondrial disease patients.

bioRxiv · Nov 29, 2021Cell Biology

Energy deficit-independent stress response in the Frataxin-depleted heart: evidence that Integrated Stress Response can predominate over mTORC1 activation

C. Vasquez, M. Patel, A. Sivaramakrishnan, C. Bekeova, L. Anderson-Pullinger, N. Wang, H.-Y. Tang, E. L. Seifert

This study shows that in FXN-depleted hearts, the integrated stress response (ISR) predominates over mTORC1 activation, despite reduced energy production, suggesting a protective mechanism.

bioRxiv · Jun 12, 2020 · PreprintBiochemistry

Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues

E. L. Varner, S. Trefely, D. Bartee, E. von Krusenstiern, L. Izzo, C. Bekeova, R. S. O'Connor, E. L. Seifert, K. Wellen, J. L. Meier, N. W. Snyder

This paper quantifies lactoyl-CoA in mammalian cells and tissues using LC-HRMS and provides a biosynthetic method for isotopically labeled lactoyl-CoA.

bioRxiv · Mar 15, 2020 · PreprintBiochemistry

Multiple acyl-CoA thioesterases occupy distinct functional niches within the mitochondrial matrix

C. Bekeova, L. Anderson-Pullinger, K. Boye, F. Boos, Y. Sharpadskaya, J. M. Herrmann, E. L. Seifert

The paper identifies distinct functional roles of mitochondrial Acot enzymes based on substrate specificity and CoA inhibition, revealing their roles in regulating beta-oxidation and preventing lipotoxicity.

bioRxiv · Jul 16, 2019 · PreprintBiochemistry