Author

Yan Yang

Chinese Academy of Tropical Agricultural Sciences

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Biology Disciplines

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Cancer Biology· 2 Genomics· 2 Molecular Biology· 2 Biophysics· 1 Genetics· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:whole-genome sequencing· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:protein structure· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Alejandra G. SerranoiD· 1 shared Alexa Halliday· 1 shared Alysson Renato MuotriiD· 1 shared Amaia Hervas GiD· 1 shared Amalio TelentiiD· 1 shared Amir M. H. IbrahimiD· 1 shared Azusa TanimotoiD· 1 shared Bhooma ThiruvahindrapuramiD· 1 shared

Activity by Year

2017-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCancer Biology

Alejandra G. SerranoORCID

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Author profile →

9 papers

Recent·Most cited

YAP1 defines an emergent, plastic population of relapsed small cell lung cancer

Catherine Allison Stewart, Kavya Ramkumar, Runsheng Wang, Yuanxin Xi, Alexa Halliday, Lixia Diao, Qi Wang, Alejandra G. Serrano, Sarah Groves, Simon Heeke, Azusa Tanimoto, Laura Kaiser, Yan Yang, Whitney E. Lewis, Jody V. Vykoukal, , Carl Michael Gay

This study identifies YAP1-positive cells in relapsed SCLC that exhibit drug tolerance and transition from SCLC to LCNEC-like features, losing some targets but gaining others.

Journal of Thoracic Oncology · Apr 20, 2026Peer-reviewedCancer Biology

Structural Basis of M1 Muscarinic and H3 Histamine Receptor Inhibition in OPC Differentiation

Bryan A. Raubenolt, Fabio Cumbo, Jayadev Joshi, William C. Martin, Satish Medicetty, Yan Yang, Bruce D. Trapp, Daniel J Blankenberg

The paper identifies M1 muscarinic and H3 histamine receptors as targets for OPC differentiation and analyzes their ligand interactions using computational methods.

bioRxiv · Apr 2, 2026 · PreprintBiophysics

Non-invasive and painless mid-infrared modulation increases collagen in human and mouse skin

Zeyu Wang, Jiahui Zhu, Yuting Wang, Tianxing Hu, Shuai Chen, Senlin Xu, Yaoying Li, Xiang Liao, Shanshan Liang, Yang E. Li, Xuanyue Wang, Sunny C. Li, Yan Yang, Hongbo Jia, Xiaowei Chen, , Jianxiong Zhang

Mid-infrared modulation promotes collagen production in human and mouse skin without pain or trauma.

Journal of Advanced Research · Jan 30, 2026Peer-reviewedMolecular Biology

Complete telomere-to-telomere genomes of cowpea reveal insights into centromere evolution in Phaseoleae

Chuanzheng Wei, Shichao Sun, Yinzi Wang, Li Liu, Sofie Pearson, YanBo Wang, Tashi Dorjee, Emma Mace, David Robert Jordan, Yan Yang, Yongfu Tao

The paper presents complete telomere-to-telomere cowpea genomes, revealing centromere evolution and subspecies divergence in Phaseoleae.

Horticulture Research · Dec 26, 2025Peer-reviewedGenomics

Ammonia-mediated Conformational Dynamics in SCAP for SREBP Activation

Kevin C. Chan, Zoe Li, Yan Yang, Deliang Guo, Xiaolin Cheng

This study uses molecular dynamics simulations to show ammonia induces conformational changes in SCAP that activate the SREBP pathway by promoting dissociation from Insig.

bioRxiv · May 29, 2025 · PreprintMolecular Biology

Genome wide identification of QTL associated with yield and yield components in two popular wheat cultivars TAM 111 and TAM 112

Yan Yang, Smit Dhakal, Chenggen Chu, Shichen Wang, Qingwu Xue, Jackie C. Rudd, Amir M. H. Ibrahim, Kirk E. Jessup, Jason A. Baker, Maria Pilar Fuentealba, Ravindra N. Devkota, Shannon A. Baker, Charles D. Johnson, Richard P. Metz, Shuyu Liu

This study identifies QTL associated with yield and yield components in two wheat cultivars under different environmental conditions.

PLoS ONE · Dec 2, 2020Peer-reviewedGenetics

Paternally inherited noncoding structural variants contribute to autism

William M. Brandler, Danny Antaki, Madhusudan Gujral, Morgan L. Kleiber, Joe Whitney, Michelle S. Maile, Oanh Hong, Timothy R. Chapman, Shirley Tan, Prateek Tandon, Timothy Pang, Shih C. Tang, Keith K. Vaux, Yan Yang, Eoghan Donal Harrington, , Jonathan L. Sebat

This study identifies rare paternally-inherited structural variants contributing to autism by disrupting noncoding regions and coding genes, with differential parental contributions.

Science · Apr 20, 2018Peer-reviewedGenomics

Evolution of an intratumoral ecology susceptible to successive treatment in breast cancer xenografts

Hyunsoo Kim, Pooja Kumar, Francesca Menghi, Javad Noorbakhsh, Eliza Cerveira, Mallory Ryan, Qihui Zhu, Guruprasad Ananda, Joshy George, Henry C. Chen, Susan Mockus, Chengsheng Zhang, Yan Yang, James Keck, R. Krishna Murthy Karuturi, , Jeffrey H. Chuang

This study quantifies intratumoral subclone dynamics in breast cancer xenografts, revealing a treatable ecology where subclone ratios predict treatment response.

bioRxiv · Jan 18, 2018 · PreprintCancer Biology

Parsing Of Compositions And Microstructure Characteristics For Rust-Spots Of Pear Pericarp

Lijun Nan, Shaobo Chen, Yashan Li, Ya Liu, Ying Jiang, Yan Yang, Chengdong Xu, Guogang Chen

The paper identifies chemical compounds in rust spots of Kurle pears using HPLC and LC-MS, linking them to microstructural changes during storage.

bioRxiv · May 27, 2017 · PreprintPlant Biology