Yanabel Grant

Effects of vapor inhalation of 6-methyl nicotine in female and male rats

This study examines the effects of 6-methyl nicotine (6-MN) vapor inhalation in rats, finding similar physiological and behavioral responses to nicotine.

Impact of Sex on Heroin Intravenous Self-Administration by Heterogeneous Stock Rats

This study finds that female Heterogeneous Stock rats self-administer opioids more frequently than males in various conditions, while males show greater sensitivity to heroin's anti-nociceptive effects.

Impact of Age on Heroin Intravenous Self-Administration in Wistar Rats

This study investigates age-related differences in heroin's anti-nociceptive and rewarding effects in rats, finding diminished opioid reward in middle-aged males.

Methamphetamine and α-pyrrolidinopentiophenone (α-PVP) Intravenous Self-Administration in Female and Male Rats

This study compares methamphetamine and α-PVP self-administration in male and female rats, finding sex differences in reinforcement and dose effects.

Effects of 6-methyl nicotine in middle aged female rats with a history of nicotine vapor self-administration

This study compares the physiological and behavioral effects of 6-methyl nicotine and nicotine in rats, finding similar effects on temperature, activity, and nociception.

Δ9-tetrahydrocannabinol (THC) Increases the Rewarding Value of Oxycodone During Self-Administration in Rats

This study shows that THC increases oxycodone self-administration in rats, suggesting it enhances opioid reinforcement and addiction risk.

Self-Administration of entactogen psychostimulants dysregulates GABA and Kappa Opioid Receptor signaling in the central nucleus of the amygdala of female Wistar rats

This study shows that female rats escalate self-administration of entactogen psychostimulants under long-access conditions, leading to increased GABAergic inhibition and altered KOR signaling in the central nucleus of the amygdala.

Paradoxical changes in brain reward status during oxycodone self-administration in a novel test of the negative reinforcement hypothesis

This study examines how oxycodone self-administration affects brain reward status in rats, finding that prolonged access leads to increased reward thresholds, which normalize during abstinence.

Δ9-tetrahydrocannabinol Attenuates Oxycodone Self-Administration Under Extended Access Conditions

This study investigates whether THC reduces oxycodone self-administration in rats under extended access conditions and finds additive antinociceptive effects when THC and oxycodone are combined.

Tolerance to hypothermic and antinoceptive effects of∆9-tetrahydrocannabinol (THC) vapor inhalation in rats

This study investigates tolerance to THC's hypothermic and antinociceptive effects in rats through repeated vapor inhalation, finding gender differences in tolerance development.

Prophylactic vaccination protects against the development of oxycodone self-administration

This study shows that a vaccine against oxycodone reduces its reinforcing effects and prevents self-administration in rats.

Binge-like Acquisition of α-pyrrolidinopentiophenone (α-PVP) Self-Administration in Female Rats

The study investigates binge-like self-administration of α-PVP in female rats and finds that half exhibit high initial intake, with wheel activity devalued as a reward.

Withdrawal-induced escalated oxycodone self-administration is mediated by kappa opioid receptor function

This study shows that extended oxycodone self-administration in rats leads to escalated drug use and dysregulation of KOR-mediated GABAergic signaling in the CeA, with distinct neuroadaptive effects compared to other drugs.