Jacques D. Nguyen

This study examines how repeated fentanyl administration affects perineuronal nets and parvalbumin expression in rat orbitofrontal cortex, showing changes in antinociceptive tolerance and PNN/PV correlations.

This study shows semaglutide reduces fentanyl self-administration and withdrawal-like behavior in female rats, suggesting its potential as a treatment for opioid use disorder.

This study examines the neurobehavioral effects of dry hit nicotine e-cigarette vapor on adolescent rats, finding similar behavioral responses to saturated nicotine but distinct changes in perineuronal net expression.

This study shows that THC increases oxycodone self-administration in rats, suggesting it enhances opioid reinforcement and addiction risk.

This study shows THC enhances oxycodone self-administration in female rats under progressive ratio schedules, while CBD reduces it in fixed ratio schedules.

This study shows that female rats escalate self-administration of entactogen psychostimulants under long-access conditions, leading to increased GABAergic inhibition and altered KOR signaling in the central nucleus of the amygdala.

This study examines how oxycodone self-administration affects brain reward status in rats, finding that prolonged access leads to increased reward thresholds, which normalize during abstinence.

This study shows that Reelin deficiency exacerbates long-term behavioral issues in mice exposed to THC during adolescence, including impaired social behavior and increased novelty seeking.

This study investigates whether THC reduces oxycodone self-administration in rats under extended access conditions and finds additive antinociceptive effects when THC and oxycodone are combined.

This study investigates tolerance to THC's hypothermic and antinociceptive effects in rats through repeated vapor inhalation, finding gender differences in tolerance development.

This study shows that a vaccine against oxycodone reduces its reinforcing effects and prevents self-administration in rats.

The study investigates binge-like self-administration of α-PVP in female rats and finds that half exhibit high initial intake, with wheel activity devalued as a reward.

This study compares the locomotor and reinforcing effects of pentedrone, pentylone, and methylone in rats, finding that pentedrone and pentylone have greater abuse liability than methylone.

This study shows that extended oxycodone self-administration in rats leads to escalated drug use and dysregulation of KOR-mediated GABAergic signaling in the CeA, with distinct neuroadaptive effects compared to other drugs.