Yang Yu

Interspecific hybrids reveal a deeply conserved nuclear role of EIF1A-family proteins in zygotic genome activation

The paper uses interspecific hybrid embryos to identify EIF1A-family proteins as conserved nuclear regulators of zygotic genome activation across mammals.

A Principled Statistical Framework for Analyzing Spatial Patterns in Spatially Resolved Multi-Omics

This paper introduces STORM, a statistical framework for analyzing spatial patterns in multi-omics data, demonstrating reliable performance in detecting spatial structures and supporting study design decisions.

A Time-Sequenced Three-Drug-Loaded Microneedle Patch for the Prevention of Vein Graft Restenosis After Coronary Artery Bypass Grafting

This paper develops a microneedle patch that sequentially releases three drugs to prevent vein graft restenosis after CABG, showing reduced thrombosis, intimal hyperplasia, and improved graft patency in mice.

Dissociable neural substrates of integration and segregation in exogenous attention

This study identifies dissociable neural signatures for integration and segregation processes in exogenous attention using fMRI, supporting the integration-segregation theory.

Regulation of neuroinflammation by astrocyte-derived cholesterol.

This study shows that astrocyte-derived cholesterol, released via apoE, promotes neuroinflammation by enhancing inflammatory signaling in immune cells.

Define and visualize pathological architectures of human tissues from spatially resolved transcriptomics using deep learning

RESEPT uses deep learning to visualize and characterize tissue architecture from spatial transcriptomics data, revealing pathological structures in Alzheimer's and glioblastoma samples.

Neuron Type-Specific Mechanical Regulation Of Voltage-Gated Ca2+ Channels And Excitability In Hippocampal And Trigeminal Ganglion Neurons

This study shows that substrate stiffness differentially regulates voltage-gated Ca2+ channels and excitability in hippocampal and trigeminal ganglion neurons.