CXCL-CXCR2 signaling drives cancer-endothelium interactions in SCLC metastatic seeding
Zhang Yang, Andy Xu, Nicholas W. Hughes, Chien‐Wei Peng, Adrienne V. Visani, Susrutha Puthanmadhom Narayanan, Xue Wen Ng, Isabella Guppy, Chris Roberts, Yanhui You, Monte M. Winslow, David W. Piston, Jon Park, Zhonglin Lyu, Feng Chen, , Rui Tang
This study identifies CXCL-CXCR2 signaling as critical for SCLC liver metastasis by enhancing cancer cell migration and interactions with endothelial cells.
bioRxiv · Oct 12, 2026 · PreprintCancer Biology