Rui Tang

This study identifies CXCL-CXCR2 signaling as critical for SCLC liver metastasis by enhancing cancer cell migration and interactions with endothelial cells.

This paper introduces MOBA-seq, a platform to map genetic regulators of metastasis at single-colony resolution, identifying tissue-specific suppressors and universal essential genes.

This study shows aging suppresses lung tumor initiation and growth in mice, with age-dependent effects on tumor suppressor genes like PTEN and persistent age-related transcriptomic changes in tumors.

This study develops transgenic Cas12a mice to enable efficient, multiplexed somatic genome editing for studying complex genetic interactions in vivo.

This study identifies GAS5 as a regulator of TGF-β-induced fibroblast activation by inhibiting Smad3 signaling, showing therapeutic potential for fibrotic diseases.