Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy
Binjie Guo, Hanyu Zheng, Haohan Jiang, Xiaodan Li, Naiyu Guan, Yanming Zuo, Yicheng Zhang, Hengfu Yang, Xuhua Wang
This paper introduces FeatNN, a coevolutionary strategy for predicting compound-protein binding affinity by jointly representing protein sequence and structure information, achieving higher accuracy than existing methods.
Briefings in Bioinformatics · Dec 26, 2022Peer-reviewedBioinformatics