Epithelial cells of the intestine acquire cell-intrinsic inflammation signatures during ageing
Maja C. Funk, Jan Gleixner, Florian Heigwer, Dominik Vonficht, Erica Valentini, Zeynep Aydin, Elena Tonin, Stefania Prete, Sylvia Mahara, Yannick Throm, Jenny Hetzer, Danijela Heide, Oliver Stegle, Duncan T. Odom, Angelika Feldmann, , Michael Boutros
This study shows that aged intestinal epithelial cells exhibit a persistent inflammation signature, marked by MHC class II upregulation and increased chromatin accessibility of inflammation-associated loci.
Developmental Cell · Dec 1, 2023Peer-reviewedGenomics