Author

Zeynep Aydin

German Cancer Research CenterPrimary ORCID profile (0009-0000-4377-8865 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Zeynep AydiniD1 paper · Koç University

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Ana Martín-VillalbaiD· 1 shared Andrés Sanz-MorejóniD· 1 shared Angelika FeldmanniD· 1 shared Aylin Korkmaz· 1 shared Bingbing YuaniD· 1 shared Danijela HeideiD· 1 shared Dheeraj MalhotraiD· 1 shared Dominik VonfichtiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperNeuroscience

Ana Martín-VillalbaORCID

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3 papers

Recent·Most cited

Joint recording of past and present transcriptomes reconstructs single-cell trajectories

Zeynep AYDIN, Svetlana Ovchinnikova, Iris A. Unterweger, Santiago Cerrizuela, Naomie PONT, Valentin Wüst, Ruben Boers, Katharina Zirngibl, Ozgur CAN, Matteo Spatuzzi, Tatiana Traboulsi, Xiaoyu Sun, Aylin Korkmaz, Sara Ortica, Tanya Foley, , Laure Bally‐Cuif

This paper introduces scReMeMber-Seq, a method to reconstruct single-cell trajectories by linking past and present transcriptomes using methylation-based memory recording.

bioRxiv · Sep 30, 2026 · PreprintNeuroscience

Functional genomic dissection of MS risk loci reveals convergence of cis and trans gene regulatory mechanisms in microglia

Michael D. Gallagher, Xochitl Luna, Wenjuan Du, Kathryn E.A. Hazel, Moritz List, Zeynep Aydin, Orian Stapleton, Yiran Cheng, Bingbing Yuan, Keya Viswanathan, Heather R. Keys, George W. Bell, Dheeraj Malhotra, Richard A. Young, Rudolf Jaenisch, Olivia Corradin

The paper identifies cis and trans gene regulatory mechanisms in microglia linked to multiple sclerosis risk SNPs using computational and CRISPR perturbation approaches.

medRxiv · Jun 16, 2025 · PreprintGenetic & Genomic Medicine

Epithelial cells of the intestine acquire cell-intrinsic inflammation signatures during ageing

Maja C. Funk, Jan Gleixner, Florian Heigwer, Dominik Vonficht, Erica Valentini, Zeynep Aydin, Elena Tonin, Stefania Prete, Sylvia Mahara, Yannick Throm, Jenny Hetzer, Danijela Heide, Oliver Stegle, Duncan T. Odom, Angelika Feldmann, , Michael Boutros

This study shows that aged intestinal epithelial cells exhibit a persistent inflammation signature, marked by MHC class II upregulation and increased chromatin accessibility of inflammation-associated loci.

Developmental Cell · Dec 1, 2023Peer-reviewedGenomics